New Delhi: Japanese researchers has successfully treated spinal fractures in rats using stem cells from fatty tissue. They conducted the study at Osaka Metropolitan University, focusing on fractures similar to those caused by osteoporosis in humans.
The scientists extracted stem cells from adipose tissue, which is easy to collect and causes little stress to the body. Consequently, this method suggests a non-invasive way to treat bone diseases, even in elderly patients.
They developed the stem cells into bone-differentiated spheroids, three-dimensional clusters that can help bone regeneration. Then, they combined these spheroids with beta-tricalcium phosphate, a material commonly used for bone reconstruction.
As a result, the rats showed improved bone strength and faster recovery. Moreover, the genes involved in bone formation and repair were activated, enhancing the healing process significantly.
“This study shows the potential of ADSC spheroids for new spinal fracture treatments,” said Yuta Sawada, a student at the Graduate School of Medicine. Additionally, Dr. Shinji Takahashi highlighted that using fat-derived cells reduces the burden on the body and ensures patient safety.
Osteoporosis makes bones brittle and prone to fractures, especially in the spine. Osteoporotic vertebral fractures are the most common type, often leading to long-term care and reduced quality of life. Therefore, new treatments are urgently needed to support patients’ health.
Since stem cells are multipotent, they can transform into many cell types. By using ADSCs in bone spheroids, researchers created a simple, effective, and safe approach. Consequently, this technique may accelerate fracture healing and extend patients’ healthy lives.